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TCL (GTPase)
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TCL (GTPase) : ウィキペディア英語版
TCL (GTPase)
TCL is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rho family of GTPases.,.
TCL (TC10-like) shares 85% and 78% amino acid similarity to TC10 and Cdc42, respectively. TCL mRNA is 2.5 kb long and is mainly expressed in heart. In vitro, TCL shows rapid GDP/GTP exchange and displays higher GTP dissociation and hydrolysis rates than TC10. Like other Rac/Cdc42/RhoUV members, GTP-bound TCL interacts with CRIB domains, such as those found in PAK and WASP. TCL produces large and dynamic F-actin-rich ruffles on the dorsal cell membrane in REF-52 fibroblasts. TCL activity is blocked by dominant negative Rac1 and Cdc42 mutants, suggesting a cross-talk between these three Rho GTPases.
TCL is unrelated to TCL1A, a proto-oncogene implicated in the development of T-Cell Leukemias.
==See also==

*TCL1A

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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